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Use of the phrase "artificial cannabis" to explain products containing synthetic cannabinoids is controversial and, according to Lewis Nelson, a professional medical toxicologist at the NYU School of Drugs, a oversight. Nelson statements that relative to cannabis, goods containing synthetic cannabinoids "are definitely pretty various, and the effects are way more unpredictable.

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PB-22 and 5F-PB-22 have been the main artificial cannabinoids to incorporate a quinoline substructure and an ester linkage. These compounds are thought to are actually synthesized Along with the intention of constructing a synthetic cannabinoid prodrug, which might improve absorption and confound detection. Ester bonds are conveniently biodegradable by way of spontaneous or endogenous, nonspecific esterase hydrolysis, that has been generally Employed in medicinal chemistry to produce ester prodrugs.

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[eighty three] HU-210 is a chiral compound initial synthesized by Raphael Mechoulam at Hebrew University from the eighties. It had been learned in herbal incense goods because of the U.S. Customs and Border Protection in January 2009; however, classical cannabinoids are hardly noticed in artificial cannabinoid blends for recreational use, likely mainly because they are hard to synthesize.[84]

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